Cytokines are small secreted signaling proteins released by cells, which have a specific effect on the interactions and communications between cells. Cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Some cytokines enhance or inhibit the action of other cytokines in complex ways. Cytokines act via binding to specific cell-surface receptors and activating downstream intracellular signaling, which leads to changes in function or phenotype. Cytokines regulate diverse biological functions including innate and acquired immunity, hematopoiesis, inflammation and repair, and proliferation through mostly extracellular signaling. Cytokines may act on the cells that secrete them (autocrine action), on nearby cells (paracrine action), or in some instances on distant cells (endocrine action).
MedChemExpress (MCE) offers a comprehensive catalog of recombinant cytokines with excellent lot-to-lot consistency, superior activity and significantly low endotoxin levels. MCE cytokines include: interleukins, chemokines, interferons, tumor necrosis factors (TNFs), colony-stimulating factors (CSFs), and TGF-beta superfamily members. Product quality is the key to our success and we take pride in offering only the highest-grade products. Product identity, quality, purity and activity are assured by our robust quality control and assurance polices, programs and procedures.